What is Exosome Therapy?

You’ve probably seen that one of the hottest areas of regenerative medicine treatment right now is exosome therapy. You have probably heard about Stem Cells. Exosomes are the messenger portion of Stem Cells. So what is exosome therapy? What are exosomes exactly? Do exosomes have something to do with stem cells? How are exosomes made? Let’s dive in. 

Exosomes are extracellular vesicles (particles that release naturally from a cell that cannot replicate) that are responsible for certain genetic information, otherwise known as Exosomes cell to cell communication. They transport molecules that are essential regulators of intracellular information between close and distant cells.

Exosomes play a vital role in the communication and rejuvenation of all the cells in our body. Despite not being a cell, Exosomes have proven to be quite important in maintaining a healthy cellular terrain.

The Exosomes we offer are derived from the Wharton's Jelly from the umbilical cord of full-term cesarean delivery donated placentas. The Exosomes are then harvested from the stem cells contained in the Wharton's Jelly. These Exosomes contain different molecular constituents of their cell origin; these include proteins and mRNA. Meanwhile, the Exosomal proteins composition varies with the cell and tissue of the origin; most Exosomes contain an evolutionarily conserved common set of protein molecules. Exosomes are also acellular and the risk of a person having a reaction to the infusion is nearly zero. 

HOW TO ISOLATE EXOSOME FROM CULTURE STEM?

Exosomes are isolated from the stem cell using the method of Ultracentrifugation. Often combined with sucrose density gradients, they float the relatively low-density Exosomes from other microvesicles. Cells and larger particles are removed by sequentially increasing the centrifugal forces. These procedures can take up to 30hours and require an ultracentrifuge, extensive training and specialized equipment.

This method provides highly enriched exosomes but requires specialized training and equipment.

Now, this is how Exosomes works:

Exosomes carry genetic information. Protein and messenger RNA, they can relay this information, letting cells know when to and how to react. This Exosomes cell-to-cell communication is possible due to its unique shape and content. Exosomes are also small enough to pass through the blood-brain barrier.

Exosomes from young stem cells rejuvenate the older cells and assist in calming an overactive immune system or modulating it to respond in a coordinated and more effective fashion.

WHAT IS EXOSOME THERAPY?

Exosome therapy is one of the hottest areas of regenerative medicine treatment. Researchers have given us valuable insight into the practical functionality of exosomes. While stem cells are usually responsible for the rejuvenation of older cells, they may not be able to supply all the information needed. So supporting Exosome function could have a greater positive effect, by providing a new piece of information to enhance the healing process.

Exosome therapy is a minimally invasive procedure commonly used in orthopedic injuries, for anti-aging and some other degenerative diseases. Exosome treatment contains growth factors, messenger RNA, micro RNA, cytokines and other biologically active molecules in conjunction with stem cell therapy to speed up healing benefit.

Exosome therapy can be injected into the affected area like in orthopedic injuries or given intravenously for anti-aging. We only offer IV infusion of our Exosomes.

Exosome treatment is gaining popularity recently, due to its ability to transfer molecules from one cell to another via membrane vesicles, therefore influencing the immune system, such as dendritic cells and B cells.

What is exosome therapy used for?

LYME DISEASE: Exosomes may help to regulate processes in the body, and may also be beneficial to patients with Lyme disease. Lyme disease is a very complex disease, which compromises the immune system. Many Lyme patients suffer from dysfunction of the mast cells, increasing their inflammatory response and metabolic function. Incorporating Exosomes treatment in their treatment regimen may help break the inflammatory response and provide the body with necessary cellular information to facilitate healing.

ARTHRITIS: Arthritis as we all know, is the joint inflammation resulting from an autoimmune disease. Although various types of treatment are available to alleviate symptoms, no known therapy has been confirmed effective in reversing the disease progression.

In the field of regenerative medicine today, with the discovery of extracellular microvesicles, especially exosomes, many researchers have been able to offer a more exciting alternative on this subject matter. Exosome arthritis therapy is believed to play a more substantial role in bone and cartilage remodeling.

In a nutshell, Exosomes provides enormous potential in the field of regenerative medicine. Infusions are recommended at 6 month intervals and after the first infusion it can take up to 4 months to notice a benefit.

The FDA and Exosome Therapy

Existing exosome products are not FDA Approved. Also, there have not been any studies done to support the claims made in this article.

The upshot? The concept behind exosomes shows much promise, but so far, we have no clinical data in humans that show that these products work. Frankly, there isn’t even animal data on the specific products being sold.

If you would like to schedule an Exosome IV please give us a call 850-238-8563. We have exosomes ready and available. We'd be happy to schedule you for a consultation with Dr. Ramsden to see if Exosome therapy would be a good option for you.